General Description:
Weight-bearing physical activity is widely recommended for older adults to counteract age-related loss of muscle and bone. However, previous research in animals and young men has suggested that taking ibuprofen before or during exercise reduces some of the beneficial effects of that exercise session. The MOXI study will determine whether this occurs in older women and men.

Purpose of the study:
The purpose of this research study is to look at the effects of the pain reliever ibuprofen on changes in muscle and bone in response to exercise training in older adults

Outline of the Study:
Initial screening tests include a physical exam, bone density scan, treadmill exercise test, and blood tests. Women and men who qualify will begin planned exercise training for 9 months at our exercise facility. Participants will take ibuprofen or an inactive pill (placebo) on the days they exercise.

Qualifications to volunteer:
•women and men in generally good health
•60 – 75 years of age
•Not doing high-intensity weight lifting regularly but willing to start
•Not using aspirin, ibuprofen or similar drugs more than 2 days per month

Benefits for study volunteers include:
•Health screening tests
•A personalized and supervised exercise program
•Compensation for your time

This study is funded by the National Institutes of Health.
Principal Investigator: Wendy Kohrt, PhD
COMIRB #06-0769


**Interested? Please contact Marsha Steirn at 720.848.6461 or marsha.steirn@uchsc.edu**

• Location: Anschutz Medical Campus- Aurora
• it's NOT ok to contact this poster with services or other commercial interests